2016 · Nature Medicine
The natural polyamine spermidine, acting through autophagy, protected the heart and extended lifespan in mice.
Eisenberg et al. · Nature Medicine 22:1428–1438NewYoungible · six active ingredients
Six-factor longevity formula
Lifespan Essential 6 from our Youngible brand brings six ingredients together in one capsule: spermidine, ergothioneine, alpha-ketoglutarate (AKG), luteolin, R-lipoic acid and Se-methylselenocysteine. 60 capsules a bottle; take 1–2 each morning.

| Medicinal ingredients | Per capsule |
|---|---|
| Spermidine | See label |
| Ergothioneine | See label |
| Alpha-ketoglutarate (AKG) | See label |
| Luteolin | See label |
| R-lipoic acid | See label |
| Se-methylselenocysteine | See label |
Science
Representative research on the ingredients in this formula — background reading, not claims about this product.
2016 · Nature Medicine
The natural polyamine spermidine, acting through autophagy, protected the heart and extended lifespan in mice.
Eisenberg et al. · Nature Medicine 22:1428–14382020 · Cell Metabolism
AKG extended lifespan in ageing mice and shortened the time spent frail.
Asadi Shahmirzadi et al. · Cell Metabolism 32:447–456.e62016 · Biochemical and Biophysical Research Communications
Blood ergothioneine falls with age in older adults and is lower in those with cognitive decline.
Cheah et al. · Biochemical and Biophysical Research Communications 478:162–167Information on this website is general health information only. It is not medical advice and does not replace diagnosis or treatment by a physician. Dietary supplements are not medicines. These statements have not been evaluated by the U.S. Food and Drug Administration; products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, breastfeeding, under 18, taking medication or have a medical condition, consult a health care practitioner before use. Stem-cell, genetic-testing and blood-purification services must be delivered by appropriately licensed providers under local law; test results are for health-management reference only.
Partner with us
Every product is available for distribution and consignment, with OEM / ODM manufacturing; our health-management-centre model is open to partners across China and Southeast Asia.